| 1a Fase | 2a Fase | 3a Fase | Fase de Grupos | Oitavas | Quartas |
| Semi | Final |
Round:
Played
4th Round
05/04/2022 - Wednesday
19:00
Tolima
1
x
0
Independiente del Valle
05/05/2022 - Thursday
15:00
Fortaleza-CE
1
x
1
River Plate
17:00
Bragantino-SP
1
x
1
Vélez Sarsfield
19:00
Alianza Lima
1
x
1
Colo-Colo
5th Round
05/17/2022 - Tuesday
15:15
Bragantino-SP
0
x
1
Estudiantes
15:15
Caracas
0
x
0
The Strongest
15:15
Peñarol
0
x
0
Cerro Porteño
17:30
Boca Juniors
1
x
1
Corinthians-SP
17:30
Flamengo-RJ
3
x
0
Universidad Católica
17:30
Sporting Cristal
0
x
0
Talleres
05/18/2022 - Wednesday
15:00
Athletico-PR
2
x
0
Libertad
15:00
Nacional-URU
2
x
3
Vélez Sarsfield
15:00
Palmeiras-SP
1
x
0
Emelec
17:00
Colón
2
x
1
Olimpia
17:00
Deportivo Tachira
3
x
0
Independiente Petrolero
17:00
Tolima
2
x
2
América-MG
19:00
Alianza Lima
0
x
2
Fortaleza-CE
05/19/2022 - Thursday
15:00
Atlético-MG
3
x
1
Independiente del Valle
17:00
River Plate
4
x
0
Colo-Colo
19:00
Deportivo Cali
3
x
0
Always Ready
6th Round
05/24/2022 - Tuesday
15:15
Nacional-URU
3
x
0
Bragantino-SP
15:15
Vélez Sarsfield
4
x
0
Estudiantes
17:30
Emelec
7
x
0
Independiente Petrolero
17:30
Flamengo-RJ
2
x
1
Sporting Cristal
17:30
Palmeiras-SP
4
x
1
Deportivo Tachira
17:30
Universidad Católica
0
x
1
Talleres
05/25/2022 - Wednesday
15:00
Colo-Colo
3
x
4
Fortaleza-CE
15:00
River Plate
8
x
1
Alianza Lima
17:00
Atlético-MG
1
x
2
Tolima
17:00
Cerro Porteño
0
x
1
Olimpia