| 1a Fase | 2a Fase | 3a Fase | Fase de Grupos | Oitavas | Quartas |
| Semi | Final |
Round:
Played
2nd Round
04/14/2022 - Thursday
17:00
Vélez Sarsfield
2
x
2
Bragantino-SP
19:00
Emelec
1
x
1
Deportivo Tachira
3rd Round
04/26/2022 - Tuesday
15:15
Estudiantes
2
x
0
Bragantino-SP
15:15
Independiente Petrolero
1
x
2
Deportivo Tachira
15:15
Libertad
1
x
0
Athletico-PR
15:15
Vélez Sarsfield
1
x
2
Nacional-URU
17:30
Corinthians-SP
2
x
0
Boca Juniors
17:30
Independiente del Valle
1
x
1
Atlético-MG
17:30
Talleres
1
x
0
Sporting Cristal
04/27/2022 - Wednesday
15:00
América-MG
2
x
3
Tolima
15:00
Fortaleza-CE
2
x
1
Alianza Lima
17:00
Cerro Porteño
1
x
0
Peñarol
17:00
Colo-Colo
1
x
2
River Plate
17:00
Emelec
1
x
3
Palmeiras-SP
19:00
The Strongest
1
x
1
Caracas
04/28/2022 - Thursday
15:00
Universidad Católica
2
x
3
Flamengo-RJ
17:00
Olimpia
0
x
0
Colón
19:00
Always Ready
2
x
2
Deportivo Cali
4th Round
05/03/2022 - Tuesday
15:15
Caracas
1
x
0
Libertad
15:15
Deportivo Tachira
1
x
4
Emelec
15:15
The Strongest
5
x
0
Athletico-PR
17:30
América-MG
1
x
2
Atlético-MG
17:30
Estudiantes
1
x
0
Nacional-URU
17:30
Independiente Petrolero
0
x
5
Palmeiras-SP
05/04/2022 - Wednesday
15:00
Colón
2
x
1
Cerro Porteño
15:00
Talleres
2
x
2
Flamengo-RJ
17:00
Always Ready
0
x
1
Boca Juniors
17:00
Deportivo Cali
0
x
0
Corinthians-SP
17:00
Olimpia
1
x
0
Peñarol
19:00
Sporting Cristal
1
x
1
Universidad Católica