| 1st Qualifying Round | 2nd Qualifying Round | 3rd Qualifying Round | Play-offs | Group Stage | Round of 16 |
| Quarterfinals | Semifinals | Final |
Round:
Played
1st Round
09/15/2021 - Wednesday
09:45
Beşiktaş
1
x
2
Borussia Dortmund
12:00
Sporting CP
1
x
5
Ajax
2nd Round
09/28/2021 - Tuesday
09:45
Ajax
2
x
0
Beşiktaş
12:00
Borussia Dortmund
1
x
0
Sporting CP
3rd Round
10/19/2021 - Tuesday
09:45
Beşiktaş
1
x
4
Sporting CP
12:00
Ajax
4
x
0
Borussia Dortmund
4th Round
11/03/2021 - Wednesday
13:00
Borussia Dortmund
1
x
3
Ajax
13:00
Sporting CP
4
x
0
Beşiktaş
5th Round
11/24/2021 - Wednesday
09:45
Beşiktaş
1
x
2
Ajax
12:00
Sporting CP
3
x
1
Borussia Dortmund
6th Round
12/07/2021 - Tuesday
12:00
Ajax
4
x
2
Sporting CP
12:00
Borussia Dortmund
5
x
0
Beşiktaş